ZDLD20 是一种 β-咔啉，是一种选择性、具有口服活性的CDK4/CycD3抑制剂，IC50值为 6.51 μM。ZDLD20 表现出有效的抗 HCT116 活性，包括抑制集落形成、抑制侵袭和迁移、诱导细胞凋亡和阻止细胞周期的 G1 期。ZDLD20 表现出有效的抗癌活性。

ZDLD20, a β-carboline, is orally active and selective CDK4/CycD3 inhibitor with an IC 50 value of 6.51 μM. ZDLD20 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD20 exhibits potent anticancer activity [1].

2762279-02-5

C22H22N6O

386.45

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years