ZDLD13 是一种 β-咔啉，是一种选择性、具有口服活性的CDK4/CycD3抑制剂，IC50值为 0.38 μM。ZDLD13 表现出有效的抗 HCT116 活性，包括抑制集落形成、抑制侵袭和迁移、诱导细胞凋亡和阻止细胞周期的 G1 期。ZDLD13 在 HCT116 肿瘤异种移植模型中显示出显着的肿瘤生长抑制作用。

ZDLD13, a β-carboline, is an orally active and selective CDK4/CycD3 inhibitor with an IC 50 value of 0.38 μM. ZDLD13 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD13 shows significant tumor growth inhibition in HCT116 tumor xenograft model [1].

2762278-95-3

C18H14N4O

302.33

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years