Diquat is a bipyridylium herbicide that, as a stable radical, acts as an electron acceptor in the electron transport chain and is reoxidized by molecular oxygen, producing reactive oxygen species (ROS).1Diquat administration has been used to induce oxidative stressin vitroand in animal models.2,3,4It increases the production of ROS and decreases the mitochondrial membrane potential in mitochondria isolated from porcine intestine leading to mitophagy when administered at a dose of 100 mg/kg.2Formulations containing diquat have been used in agriculture for crop desiccation and defoliation.

85-00-7

C12H12BrN2

264.14

Diquat (bromide)

Ethanol:Slightly soluble
DMSO:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years