CHIKV-IN-3 是一种有效的针对CHIKV-122508和CHIKV-6708的低通道抑制剂，其EC50值分别为 1.55 和 0.14 μM。CHIKV-IN-3 作用于宿主细胞以干扰病毒复制。CHIKV-IN-3 表现出极小的细胞毒性 (CC50>100 μM)。预防作用。

CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC 50 values of 1.55 and 0.14 μM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability( CC 50 >100 μM). Prophylactic effect [1].

CHIKV-IN-3 (compound (E)-42; HeLa CCL2 cells; 0.1-100 μM; 24 hours) inhibits the Chikungunya virus (CHIKV) replication with an EC 50 of 1.55 μM and demonstrates low cytotoxicity ( CC 50 =129.6 μM) [1]. CHIKV-IN-3 (HeLa CCL2 cells; 20, 40, 80 μM; 24 hours) shows the highest degree of inhibition with approximately 3.9-log reduction in viral titre (ca. 99.99% inhibition) at 80 μM [1]. Cell Cytotoxicity Assay [1] Cell Line: HeLa CCL2 cells, HeLa CCL2 cells infected with CHIKV-122508 Concentration: 0.1-100 μM Incubation Time: 24 hours Result: Inhibited the CHIKV replication with an EC 50 of 1.55 μM and demonstrated low cytotoxicity( CC 50 =129.6 μM)

C24H30ClNO

383.95

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years