Z-IETD-AFC is a fluorogenic substrate for caspase-8 and granzyme B. Upon enzymatic cleavage by caspase-8 or granzyme B, 7-amino-4-trifluoromethylcoumarin (AFC) is released and its fluorescence can be used to quantify caspase-8 or granzyme B activity. AFC displays excitation/emission maxima of 380/500 nm, respectively.

219138-02-0

C37H42F3N5O13

821.75

Z-IETD-AFC

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years