MeOSuc-Ala-Ala-Pro-Val-AMC (MeOSuc-AAPV-AMC) is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase. The methoxy succinyl (MeO-Suc) peptide AAPV is avidly hydrolyzed by these elastases but not by cathepsin G. The addition of 7-amino-4-methylcoumarin (AMC) generates a peptide of low fluorescence (excitation: 355-380 nm; emission 440-460 nm) that demonstrates a linear increase in fluorescence in the presence of elastase. This peptidyl-AMC substrate detects as little as 11 pM human leukocyte elastase and 18 pM porcine pancreatic elastase.

72252-90-5

C31H41N5O9

627.69

MeOSuc-Ala-Ala-Pro-Val-AMC

DMF:20 mg/mL
DMF:PBS(pH 7.2)(1:1):0.5 mg/mL
DMSO:16 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years