Neuroinflammatory-IN-2 (compound 7i) 是一种有效的抗神经炎症剂，对MAO-B的IC50为 10.30 μM，25 μM 时能抑制 96.33% 的 Aβ1-42聚集。Neuroinflammatory-IN-2 在H2O2诱导的 PC-12 细胞损伤中具有神经保护作用。Neuroinflammatory-IN-2 还具有生物金属螯合能力、抗氧化活性、抗神经炎症活性和适当的血脑屏障通透性 (BBB)。Neuroinflammatory-IN-2 可用于阿尔兹海默症的研究。

Neuroinflammatory-IN-2 (compound 7i) is a potent anti-neuroinflammatory agent with an IC 50 value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ 1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H 2 O 2 -induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease [1].

Neuroinflammatory-IN-2 (compound 7i) (1 and 10 μM) dramatically increases the viability of H 2 O 2 -treated PC-12 cells by 70.2% and 81.6% at 1 and 10 μM, respectively [1]. Neuroinflammatory-IN-2 (0.5, 2.5 and 10.0 μM) inhibits NO expression in LPS-stimulated BV-2 cells by 32.4%, 46.7% and 57.2% at the concentration of 0.5, 2.5 and 10.0 μM respectively; and inhibits TNF-α by 35.8%, 53.1% and 76.5%, respectively [1].

2361384-14-5

C25H27FN2O3

422.49

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years