PDE4-IN-11 是磷酸二酯酶同工酶 4 (PDE4) 抑制剂。PDE4-IN-11 具有高效的支气管扩张和抗炎特性,可用于阻塞性或炎症性气道疾病的研究。
产品描述
PDE4-IN-11 is an inhibitor of phosphodiesterase isoenzyme 4 ( PDE4 ). PDE4-IN-11 displays highly effective bronchodilatory and anti-inflammatory properties, can be used for obstructive or inflammatory airway diseases research [1] [2] [3].
体外活性
PDE4-IN-11 (example 12) exerts function in the monocrotaline reversal model of pulmonary hypertension [2]. PDE4-IN-11 (compound A1) displays anti-inflammatory, anti-airways hyperreactivity and bronch odilator properties. PDE4-IN-11 also possesses immunosuppressive and TNFα secretion inhibitory activities [3].
Cas No.
524734-30-3
分子式
C21H19FN2O2
分子量
350.393
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years