PI3K/mTOR Inhibitor-8 (Compound 18b) 是一种PI3K和mTOR双重抑制剂，对PI3Kα和 mTOR 的IC50分别为 0.46 nM 和 12 nM。PI3K/mTOR Inhibitor-8 诱导 HCT-116 细胞凋亡 (Apoptosis)，在 G1/S 期阻滞细胞周期。

PI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC 50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase [1].

PI3K/mTOR Inhibitor-8 (Compound 18b) shows anti-proliferation activities with IC 50 values of 1.95 ± 0.02, 2.02 ± 0.01, 1.62 ± 0.01 and 1.55 ± 0.01 μM against PC-3, HCT-116, A549 and MDA-MB-231 cells, respectively [1].

2492376-85-7

C23H22N8O4S

506.54

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years