Spironolactone(SC9420)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	52-01-7
规格:	≥98%

包装与价格：

包装	价格(元)
500mg	电议
1g	电议
2g	电议
5g	电议
10g	电议
100g	电议

产品介绍

Spironolactone (SC9420; SC-9420; SC 9420; Spiresis; Spiridon) is a potent androgen receptor/AR antagonist with potential antineoplastic activity. It inhibits AR with an IC50 of 77 nM. Spironolactone has been approved for the treatment of fluid build-up caused by heart failure, liver scarring, or kidney disease. It can also be used to treat high blood pressure, low blood potassium that does not improve with supplementation, early puberty, excessive hair growth in women, and as a component of hormone replacement therapy for trans women.

理化性质和储存条件

Molecular Weight (MW)	416.57
Formula	C24H32O4S
CAS No.	52-01-7
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 83 mg/mL (199.2 mM)
	Water: <1 mg/mL
	Ethanol: 20 mg/mL (48.0 mM)
Other info	Chemical Name: S-((7R,8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate InChi Key: LXMSZDCAJNLERA-NMFLDQOASA-N InChi Code: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24-/m0/s1 SMILES Code: O=C(O1)CC[C@]12CC[C@@]3([H])[C@]4([H])[C@H](SC(C)=O)CC5=CC(CC[C@]5(C)[C@@]4([H])CC[C@]23C)=O
Synonyms	SC9420; SC9420; SC-9420; Spiresis; Spiridon

实验参考方法

In Vitro	In vitro activity: Spironolactone is a strong AR antagonist (IC50 ~ 77 nM), a weak GR antagonist (IC50 ~ 2.4 μM), and a weak PR agonist (EC50 ~ 740 nM). Spironolactone inhibits androstanolone binding in rat prostate nuclei and androstanolone specific binding in rat prostate cytosol.
In Vivo	Spironolactone (1 mg/day) exerts anti-androgenic activity in rats. A single pretreatment of spironolactone (1 mg/rat) inhibits specific and saturable uptake of hormone into prostate induced by tracer dose administration of [3H]testosterone.
Animal model	Rats
Formulation & Dosage	1 mg/day
References	J Biol Chem. 2010 Sep 24;285(39):29932-40; Mol Cell Endocrinol. 1974 Dec;2(1):59-67.