FK 3311 是一种细胞渗透性和口服磺胺类药物，可作为 COX-2 抑制剂和非甾体抗炎药。

FK 3311 is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID)

Survival rate was significantly better (p<0.05) and serum GOT levels 30 min after reperfusion were significantly lower (p<0.05) in the FK 3311(FK) high-dose group compared to the other two groups. Four hours after reperfusion, GPT levels and liver tissue flow were significantly (p<0.05) better in the FK high-dose group compared to the control. Both 30 min and 4 hr after reperfusion, serum TxB(2) levels were significantly lower in the FK high-dose group compared to the control (p<0.05)[1].

Inbred male Lewis rats weighing 200-260 g were used. The donor liver was perfused with cold University of Wisconsin (UW) solution and then stored in the same solution at 4 degrees C for 18 hr. After the preservation period, orthotopic liver transplantation was performed. Animals were divided into three groups: the control group; the FK low-dose group (1 mg/kg FK3311 i.v. 20 min before reperfusion); and the FK high-dose group (3 mg/kg FK3311. 20 min before reperfusion). Survival rate, serum GOT and GPT levels, liver tissue blood flow, and serum thromboxane B(2) (TxB(2)) levels were compared among groups[1].

116686-15-8

C15H13F2NO4S

341.33

FK-3311;N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺;COX-2 Inhibitor V;FK 3311

DMSO:100 mg/mL (292.97 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years