产品描述
CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling. CBR-470-2 can be used for the research of modulation glycolysis[1].
体外活性
CBR-470-2 (1-10 μM; 24 h) increases transcript levels of the NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts[1].
体内活性
CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo[1]. Animal Model: Balb/C mice (5-week old) are exposed to UVB[1]
Cas No.
2416095-00-4
分子式
C12H13Cl2NO6S2
分子量
402.27
别名
CBR-470-2
储存和溶解度
DMSO:200 mg/mL (497.18 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years