Nonsteroidal Aromatase inhibitor 1 (Compound 13h) 是一种非甾体芳香酶 (CYP19A1) 抑制剂 (IC50=0.09 nM)，有潜力用于乳腺癌研究。

Nonsteroidal aromatase inhibitor 1 (Compound 13h) is a nonsteroidal aromatase ( CYP19A1 ) inhibitor ( IC 50 =0.09 nM). Nonsteroidal aromatase inhibitor 1 has potential for breast cancer research [1].

Nonsteroidal aromatase inhibitor 1 (0.001 pM-100 pM; 1 h) treatment shows excellent aromatase inhibition activity [1]. Nonsteroidal aromatase inhibitor 1 (1 μM; 48 h) treatment has no impact on MCF-10A or MDA-MB-231 growth [1]. Cell Viability Assay [1] Cell Line: JEG-3 cells Concentration: 0.001 pM-100 pM Incubation Time: 1 hour Result: Showed excellent aromatase inhibition with the IC 50 value of 0.09 nM. Cell Cytotoxicity Assay [1] Cell Line: MCF-10A and MDA-MB-231 cells Concentration: 1 μM Incubation Time: 48 hour Result: Suggested possible limited toxicity in normal breast tissue and little off-target effects.

C22H16N4O2

368.39

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years