Tracazolate hydrochloride是一种GABAA受体的调节剂，具有抗焦虑和抗惊厥活性。Tracazolate hydrochloride能增强α1β1γ2s和α1β3γ2，EC50s为13.2μM和1.5μM。

Tracazolate hydrochloride is a modulator of the GABAA receptor with anxiolytic and anticonvulsant activity. Tracazolate hydrochloride potentiates α1β1γ2s and α1β3γ2 with EC50s of 13.2 μM and 1.5 μM.

Tracazolate hydrochloride (10 μM) enhanced the sensitivity of α1β2δ-containing GABAA receptors and increased the maximum current amplitude in oocytes [1]. Tracazolate hydrochloride inhibited α1β1ε, α1β3ε, α1β3, and α6β3γ with EC50s of 4.0 μM, 1.2 μM, 2.7 μM, and 1.1 μM. Tracazolate hydrochloride interacted with γ-aminobutyric acid GABAA receptors, adenosine receptors, and phosphodiesterases [2].

1135210-68-2

C16H25ClN4O2

340.85

盐酸西卡唑酯;Tracazolate hydrochloride

1eq. HCl:<34.09mg/ml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years