NF-Κb/MAPK-IN-1 (compound 11a) 是一种有效的NF-Κb和MAPK通路抑制剂。NF-Κb/MAPK-IN-1 对 NO 生成具有抑制作用，其IC50为6.96 μM。NF-Κb/MAPK-IN-抑制 LPS 诱导的iNOS，COX-2，ERΚ和P38激活。 NF-Κb/MAPK-IN-1 可抑制 LPS 诱导的巨噬细胞炎症反应。 NF-Κb/MAPK-IN-1 可用于类风湿关节炎 (RA) 的研究。

NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC 50 of 6.96 μM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research [1].

2413940-56-2

C27H27NO7

477.51

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years