SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins , with a K i of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers.

SBP-0636457 (1-20 μM) demonstrates no cytotoxicity in BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines up to a concentration of 20μM[1]. SBP-0636457 (10-1000 nM; 20 h) is ef?cacious as TRAIL-sensitizing agents in MDA-MB-231 cells, with an EC 50 of 9 nM[1].

1422180-49-1

C25H36N4O4

456.58

SBP-0636457;SB1-0636457;SBI-0636457;SBP-0636457

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years