BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay).1 It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 μM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro.

934758-70-0

C10H5Cl3FN3O

308.52

BLX3887

DMF:30 mg/mL
DMSO:15 mg/mL
DMSO:PBS (pH 7.2) (1:5):0.16 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years