(+)-sparteine (sulfate pentahydrate) 是神经节阻断剂。 (+)-sparteine (sulfate pentahydrate) 竞争性阻断神经元中烟碱乙酰胆碱受体。

(+)-sparteine (sulfate pentahydrate) is a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons [1].

(+)-Sparteine (2 μM) (sulfate pentahydrate) reduces the ACh-induced current caused by activation of nicotinic ACh receptors (AChRs) in a voltage-independent manner at membrane potentials of -50 mV to +30 mV, whereas its blocking effect increased at more negative membrane potentials. (+)-sparteine (5 μM and 10 μM) (sulfate pentahydrate) reduces the amplitude of the excitatory postsynaptic currents (EPSC) and the time constant of the EPSC decay [1].

C15H38N2O9S

422.54

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years