Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM). It blocks glucagon-induced hepatic glycogenolysis in vivo. Glycogen phosphorylase inhibitor has been used to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells.

648926-15-2

C17H15ClF2N4O4

412.77

Glycogen Phosphorylase Inhibitor

DMF:5 mg/mL
DMSO:5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years