H3R antagonist 2 (Compound 23) 是一种多靶点histamine H3receptor (H3R)拮抗剂，对 hH3R 的Ki值为 170 nM。H3R antagonist 2 抑制乙酰胆碱酯酶 (acetylcholinesteRase)、丁酰胆碱酯酶 (butyrylcholinesteRase) 和人单胺氧化酶 B (human Monoamine Oxidase B (hMAO B))，IC50值分别为180、880 和 775 nM。H3R antagonist 2 具有良好的抗神经性疼痛和记忆增强作用，能透过血脑屏障。

H3R antagonist 2 (Compound 23) is a multitarget histamine H 3 receptor (H 3 R) antagonist with a K i of 170 nM for hH 3 R. H3R antagonist 2 shows inhibitory effects with IC 50 values of 180, 880 and 775 nM for acetylcholinesterase, butyrylcholinesterase and human monoamine oxidase B (hMAO B), respectively. H3R antagonist 2 shows favorable anti-neuropathic pain and memory-enhancing effects. H3R can across BBB [1].

C24H29NO3

379.49

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years