(Rac)-Calpain Inhibitor XII 是可逆的，选择性的钙蛋白酶 I (calpain I; μ-calpain) 抑制剂，Ki值为 19 nM。(Rac)-Calpain Inhibitor XII 对钙蛋白酶 II (calpain II; m-calpain; Ki=120 nM) 和组织蛋白酶 B (CAThepsin B; Ki=750 nM) 具有较低的亲和力。(Rac)-Calpain Inhibitor XII 具有研究钙蛋白酶在多种过程中的作用，包括嗜中性粒细胞趋化性，神经元信号传导和心脏对损伤的反应。

(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain) with Ki of 19 nM. (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, K i =120 nM) and cathepsin B (K i =750 nM). (Rac)-Calpain Inhibitor XII has the potential for studying the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury [1].

181769-57-3

C26H34N4O5

482.57

Calpain Inhibitor XII

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years