FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.

The binding interactions between FAK inhibitor 5 in the FAK allosteric site is mostly hydrophobic in nature.?Exposure of the allosteric pocket by the dramatic movement of Ile547 is accompanied by an equally significant movement of Arg550 in toward the allosteric binding site, where it packs along the tricyclic core of compounds 2.

1426683-30-8

C20H21N3O2S

367.47

FAK inhibitor 5

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years