FAK-IN-6 是一种有效的FAK抑制剂,IC50为 1.415 nM。FAK-IN-6 对某些癌症细胞系具有抗增殖活性。FAK-IN-6 可用于胰腺癌的研究。
产品描述
FAK-IN-6 is a potent FAK inhibitor with an IC 50 value of 1.415 nM. FAK-IN-6 has anti-proliferative activity against certain cancer cell lines. FAK-IN-6 can be used for researching pancreatic cancer [1].
体外活性
FAK-IN-6 (compound 9h) (0-10 μM; 72 h) has anti-proliferative activity against pancreatic cancer cells, lung cancer cells and lymphoma cells [1]. Cell Proliferation Assay [1] Cell Line: AsPC-1, PaCa-2, H1975, KM3/BTZ, Raji and L-02 [1] Concentration: 0-10 μM Incubation Time: 72 h Result: Exhibited anti-proliferative activity against AsPC-1, PaCa-2, H1975, KM3/BTZ, Raji and L-02 with IC 50 s of 0.9886 ± 0.0086 μM, 5.274 ± 0.9312 μM, 2.918 ± 0.0821 μM, 2.315 ± 0.2969 μM, 1.320 ± 0.2973 μM and 1.220 ± 0.2683 μM.
分子式
C25H31ClN5O6PS
分子量
596.04
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years