FAK-IN-5 (Compound 8l) 是一种FAK signaling抑制剂。FAK-IN-5 诱导细胞凋亡(Apoptosis) 和自噬 (Autophagy)。

FAK-IN-5 (Compound 8l) is a FAK signaling inhibitor. FAK-IN-5 induces cell apoptosis and autophagy [1].

FAK-IN-5 (Compound 8l) (0-50 μM, 72 h) shows antiproliferative activity against cancer cells [1]. FAK-IN-5 (Compound 8l) causes cell detachment [1]. FAK-IN-5 (Compound 8l) (0-25 μM, 24 h) induces autophagy and apoptosis in HCT-116 cells [1]. Cell Proliferation Assay [1] Cell Line: K562, CEM, G361, MCF-7 and HCT-116 Concentration: 0-50 μM Incubation Time: 72 h Result: Showed antiproliferative activity with IC 50 values of 6.3, 7.9, 6.3, 5.5 and 5.3 μM against K562, CEM, G361, MCF-7 and HCT-116 cells, respectively. Western Blot Analysis [1] Cell Line: HCT-116 Concentration: 1.25, 2.5, 5, 7, 10, 11, 17 and 25 μM Incubation Time: 1, 3, 5, 7 and 24 h Result: Caused the dephosphorylation of FAK, p130Cas and paxillin in a dose-dependent manner. The dephosphorylation of FAK at Y397 was observed at a much earlier time point. Detected the fragments of activated caspase-7 as well as the dose-dependent cleavage of poly (ADP-ribose) polymerase (PARP).

2408317-70-2

C29H29ClF3N3O4

576.01

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years