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CAY10773
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1648546-79-5
包装:25 mg
市场价:9371元

产品介绍

产品描述

CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (≥6 μM) also induces autophagy with incubation times longer than eight hours.

Cas No.

1648546-79-5

分子式

C22H17Cl2N5O

分子量

438.31

别名

CAY10773

储存和溶解度

DMSO:1 mg/mL
DMF:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years