COX-2/5-LOX-IN-1 (3a) 是一种有效的COX-2/5-LOX双重抑制剂。COX-2/5-LOX-IN-1 是苯并噻吩-2-基吡唑羧酸衍生物。COX-2/5-LOX-IN-1 显示出超过塞来昔布和吲哚美辛的最有效的镇痛和抗炎活性。COX-2/5-LOX-IN-1 显示出有效的 COX-1、COX-2 和 5-LOX 抑制活性，IC50s 分别为 12.13、0.4 和 4.96 μM。

COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of COX-2 / 5-LOX. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC 50 s of 12.13, 0.4 and 4.96 μM, respectively [1].

2410384-50-6

C14H10ClN3O4S2

383.83

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years