Neuraminidase-IN-10 是一种具有抗流感活性的神经氨酸酶 (neuraminidase) 抑制剂。Neuraminidase-IN-10 对 H1N1、H5N1 和 H5N8 的IC50值分别为 2.6 nM、5.1 nM 和 1.65 nM。

Neuraminidase-IN-10 is a potent neuraminidase (NA) inhibitor with anti-influenza activity. Neuraminidase-IN-10 is against H1N1, H5N1, and H5N8 with IC 50 values of 2.6 nM, 5.1 nM, and 1.65 nM, respectively [1].

Neuraminidase-IN-10 displays promising anti-influenza virus activity with EC 50 value of 7.28 and 0.71μM for H5N1 and H5N8, respectively in CEFs. Neuraminidase-IN-10 displays anti-influenza virus activity with EC 50 values of 0.04 ± 0.04 and 28.70 ± 1.61 μM, respectively in MDCK Cells [1]. Metabolic stability is an important indicator for the assessment of drug candidates. Neuraminidase-IN-10 exhibits a T 1/2 (min), CL int(mic) (μL/min/kg), CL int(liver) (mL/min/kg) and remaining (T=60 min) (%) values of 120.5 min, 11.5 μL/min/kg, 10.4 mL/min/kg and 73.8 mins, respectively [1].

Neuraminidase-IN-10 (0.156 mM-10 mM; injected into the eggs) showed good protection against both H5N1 and H5N8 strains in a dose-dependent manner in a chicken embryonated egg model [1]. Animal Model: SPF Chicken Embryonated Egg [1] Dosage: 0.156 mM; 0.625 mM; 2.5 mM; 10 mM Administration: Injected into the egg Result: were not as effective as OSC in this infection model, but also exhibited a certain therapeutic effect.The survival rates of Neuraminidase-IN-10 (H5N1: 100 and 40%, respectively; H5N8: 100 and 100%, respectively) at 2.5 mM and 10 mM [1].

2685786-29-0

C26H34N2O5S

486.62

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years