15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye. 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm Hg reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type prostaglandins; for example, prostaglandin F2α will produce this degree of miosis at a dose of less than 1 μg/eye.

369585-22-8

C23H32O5

388.5

15-keto Latanoprost (free acid)

Ethanol:50 mg/mL
DMSO:33 mg/mL
DMSO:PBS (1:1):500 μg/mL
DMF:50 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years