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TP508 TFA(121341-81-9 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品名称
TP508 TFA
TP508 TFA (121341-81-9 free base)
产品介绍

产品描述

TP508 TFA is a nonproteolytic thrombin peptide. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates the production of NO in human endothelial cells. It activates endothelial cells and stem cells to revascularize and regenerates tissues.

体外活性

TP508 mitigates the effects of nuclear radiation on human endothelial cells in culture restoring endothelial NO production, tube formation, and accelerating repair of radiation-induced DNA double-strand breaks. TP508 (50 μg/mL; 24 hours; HCAEC) treatment reverses radiation-induced endothelial dysfunction (ED) and loss of NO signaling by attenuating the downregulation of eNOS expression [1]. TP508 acts as an antagonist for the effects of thrombin. TP508 peptide inhibits these thrombin-induced effects through an RGD and αvβ3-related mechanism [3].

体内活性

In male CD-1 mice, the treatment of TP508 (10 mg/kg; i.v.) mitigates radiation-induced endothelial cell damage, also significantly increases survival of CD-1 mice when injected 24 h after 8.5 Gy exposure [1].

Cas No.

TP2164

分子式

C99H147N28F3O38S

分子量

2426.46

别名

TP508 TFA;TP508 TFA (121341-81-9 free base)

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years