A-841720 是一种有效的、非竞争性的、选择性的mGlu1受体拮抗剂，对人 mGlu1 受体的IC50为 10 nM。A-841720 的选择性是 mGlu5 的 34 倍 (IC50为 342 nM)，并且对一系列其他神经递质受体、离子通道和转运蛋白没有显着活性。A-841720 具有镇痛的治疗潜力。

A-841720 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC 50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC 50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has analgesic potential in a dose range [1] [2].

869802-58-4

C17H21N5OS

343.45

A 841720

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years