Aurora Kinases-IN-2 (compound 12Aj) 是一种有效的 Aurora 激酶抑制剂 (Aurora Kinases)，对 Aurora A 和 Aurora B 的IC50值分别为 90 和 152 nM。Aurora Kinases-IN-2 通过调节细胞周期蛋白 B1 和 cdc2 将细胞周期阻滞在 G2/M 期。Aurora Kinases-IN-2 可用于癌症研究。

Aurora Kinases-IN-2 (compound 12Aj) is a potent Aurora kinases inhibitor with IC 50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora Kinases-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora Kinases-IN-2 can be used for cancer research [1].

Aurora Kinases-IN-2 (compound 12Aj) (72 hours) has antiproliferative activity with IC 50 values of 11.5 μM, 1.34 μM, 7.30 μM and 1.64 μM for U87, HeLa, HepG2 and LoVo tumor cell lines, respectively [1]. Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) inhibits Aurora A and Aurora B in HeLa cells [1]. Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours; HeLa cells) results in G2/M accumulation by regulating the expression of Cyclin B1 and cdc2 [1]. Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) blocks phosphorylation of Aurora kinases in HeLa cells [1]. Western Blot Analysis [1] Cell Line: HeLa cells Concentration: 0, 1, 5 and 10 μM Incubation Time: 24 hours Result: Decreased the expression level of Aurora A and B, as well as reduced phosphorylation of Aurora A on Thr288 (p-Thr288) and Aurora B on Thr232 (p-Thr232) in a dose-dependent manner.

2241914-86-1

C22H18ClN5O3

435.86

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years