Mc-Val-Cit-PABC-PNP 是一种组织蛋白酶可裂解的 ADC 肽接头,可用于合成抗体偶联药物。
产品描述
MC-Val-Cit-PAB-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. Protein- and peptide-drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Use of specialized linkers makes them unique in their in vivo therapeutic application by providing target tissue-specific release of drug.
Cas No.
159857-81-5
分子式
C35H43N7O11
分子量
737.767
别名
Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate;马来酰亚胺基己酰-L-缬氨酸-L-瓜氨酸对氨基苄醇 对硝基苯基碳酸脂;MC-Val-Cit-PABC-PNP
储存和溶解度
DMSO:37 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years