DUPA(OtBu)-OH 是DUPA前体。其中 DUPA 是传递 Docetaxel (DTX) 的靶向基序，可用于表达前列腺特异性膜抗原的前列腺肿瘤的研究。

DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer. PSMA has a high affinity for DUPA(Ki = 8 nM).

DUPA is conjugated with PTX via a disulfide bond, which facilitates the rapid and differential drug release in tumor cells. The targeting ligand DUPA enhances the transport capability and selectivity of Paclitaxel (PTX) to tumor cells via prostate-specific membrane antigen (PSMA) mediated endocytosis.

Histological analysis indicated that DUPA-targeted Docetaxel (DTX) conjugate with longer spacer has no toxicity in major organs of treated mice.

1026987-94-9

C23H40N2O9

488.57

(S)-5-叔丁氧基-4-(3-((S)-1,5-二-叔丁氧基-1,5-二氧代-2-戊基)脲啶)-5-氧代戊酸;DUPA(OtBu)-OH

DMSO:125 mg/mL (255.85 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years