5-fluoro 203 是一种细胞毒性分子。它可激活芳香烃受体(AhR) 信号传导,诱导 CYP1A1 的转录,从而形成 DNA 加合物以及细胞周期阻滞。它可以提高活性氧水平,并激活 ERK、p38以及JNK。
产品描述
5-fluoro 203 is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells also leads to elevation of reactive oxygen species and activation of p38, JNK and ERK.
体外活性
Estrogen receptor positive (ER+; MCF-7 and T47D) breast cancer cells, estrogen receptor negative (ER?; CRL2335, MDA-MB-231, and MDA-MB-468) breast cancer cells, and nonmalignant MCF-10A cells are treated with 5F 203 or vehicle control (0.1% DMSO) for 72 h. Nonmalignant MCF-10A breast epithelial cells and MDA-MB-231 breast cancer cells were resistant to 5F 203 treatment, whereas the other cell lines showed varying sensitivity to 5F 203.
Cas No.
260443-89-8
分子式
C14H11FN2S
分子量
258.31
别名
NSC-703786;5F-203;5-fluoro 203
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years