MAC-545496 是一种抗毒剂，可逆转耐甲氧西林的菌株中的 β-内酰胺耐药性。它是糖肽抗性相关蛋白 R 的纳摩尔抑制剂，对全长GraR蛋白具有很强的结合亲和力。

MAC-545496 is a glycopeptide-resistance-associated protein R (GraR) inhibitor, is an antivirulence agent.

MAC-545496 could also serve as an antivirulence agent alone;?it attenuates MRSA virulence in Galleria mellonella larvae.?MAC-545496 inhibits biofilm formation and abrogates intracellular survival in macrophages.?Mechanistic characterization revealed MAC-545496 to be a nanomolar inhibitor of GraR, a regulator that responds to cell-envelope stress and is an important virulence factor and determinant of antibiotic resistance.

838810-96-1

C18H18ClN5O3S

419.88

MAC-545496

DMSO:250 mg/mL (595.39 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years