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Myelin Basic Protein(MBP)(68-82),guinea pig
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Myelin Basic Protein(MBP)(68-82),guinea pig图片
CAS NO:98474-59-0
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
MBP (68-82), guinea pig
豚鼠髓磷脂碱性蛋白片段68-82
Myelin Basic Protein (MBP) (68-82), guinea pig
产品介绍
MBP (68-82), guinea pig 是一种髓鞘碱性蛋白 (MBP) 的片段。

产品描述

Myelin Basic Protein (68-82), guinea pig, is a peptide with the sequence Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn.Myelin Basic Protein (MBP) (68-82), guinea pig is a fragment of myelin basic protein (MBP).

体外活性

Multiple sclerosis is the most common autoimmune disorder affecting the central nervous system. The whole blood samples are analyzed for activation capacity and the activatability of CD4+ and CD8+ T-lymphocytes by human total myelin basic protein (MBP), human MBP 104-118 fragment, and guinea pig MBP (68-82) fragment in this study. A significant increase in the number of activated T-lymphocytes was observed in the whole blood. For all three tested MBPs, this increase in activated CD4+ and CD8+ T-lymphocytes is statistically significant (p<0.01). However, this increase in activated T-cells is most prominent following incubation with human total MBP, followed by human 104-118 fragment; the smallest increase is observed following incubation with guinea pig MBP (68-82) fragment (human total MBP>huMBP-104-118>guinea pig MBP (68-82))[1].

体内活性

Whether pretreatment with bee venom acupuncture (BVA) from the same day of MBP (68-82) immunization can affect the induction and progression of experimental autoimmune encephalomyelitis (EAE) and weight loss is examined. At 5-9 days after immunization, rats in the myelin basic protein (MBP) group start displaying partial loss of tail tonus (clinical signs, 0.5) in a freely moving environment. At 10-16 days after immunization, most of the rats in the MBP group display more severe symptoms of neurological deficit including paraparesis of the hindlimb, paraplegia, tetraparesis, and tetraplegia. Whereas, rats in the MBP + BVA group display relatively slight neurological deficits in a dose-dependent manner at 11-15 days after immunization, compared to the rats in the MBP group. The onset of symptoms is slightly delayed (BVA 0.8 mg/kg, 6.4±0.6 days) and the maximal clinical score is markedly decreased (BVA 0.25 mg/kg, 3.7±0.2; BVA 0.8 mg/kg, 2.8±0.3), compared to that in the MBP group. At this time, the mean body weight of rats in the MBP group is decreased as compared to that of rats in the normal group, but it is significantly increased in rats of the MBP + BVA group as compared to rats in the MBP group[2].

Cas No.

98474-59-0

分子式

C71H113N23O28

分子量

1736.818

别名

MBP (68-82), guinea pig;豚鼠髓磷脂碱性蛋白片段68-82;Myelin Basic Protein (MBP) (68-82), guinea pig

储存和溶解度

DMSO:10mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years