BTR-1 是一种活性抗癌剂， 可激活细胞凋亡并诱导细胞死亡。它能够诱导细胞周期 S 期停滞，影响 DNA 复制。

5-Benzylidene-3-ethyl rhodanine(BTR-1) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.

5-isopropylidiene derivatives of 3-dimethyl-2-thio-hydantoin (ITH-1), 3-ethyl-2-thio-2,4-oxazolidinedione (ITO-1), and 5-Benzylidene-3-ethyl rhodanine(BTR-1), and have tested their chemotherapeutic properties. All three compounds induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, CEM. Among the compounds tested, BTR-1 was 5- to 7-fold more potent than ITH-1 and ITO-1 when compared by trypan blue and MTT assays. IC(50) value of BTR-1 was estimated to be<10μM. Both cell cycle analysis and tritiated thymidine assays revealed that BTR-1 affects DNA replication by inducing a block at S phase. BTR-1 treatment led to increased level of ROS production and DNA strand breaks suggesting activation of apoptosis for induction of cell death.

18331-34-5

C12H11NOS2

249.35

5-Benzylidene-3-ethyl rhodanine;BTR-1

DMSO:25 mg/mL (100.26 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years