TDP1 Inhibitor-2 (化合物 5) 是一种有效的TDP1(酪氨酰 -DNA 磷酸二酯酶 1) 抑制剂，其IC50为99 nM。TDP1 Inhibitor-2 也可抑制SCAN1(脊髓小脑共济失调综合征伴轴突神经病变)，其IC50为 3.5 μM.

TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC 50 of 99 nM. TDP1 Inhibitor-2 also can inhibit SCAN1 (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC 50 of 3.5 μM [1].

TDP1 Inhibitor-2 (compound 5) shows potent anti-TDP1 activity, low cytotoxicity and synergism with topotecan, an established Top1 anticancer agent [1].

859142-95-3

C25H14Cl2O5

465.28

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years