PTP1B-IN-4是一种 PTP1B 的变构抑制剂,IC50为8μM。PTP1B-IN-4可用于肥胖症和糖尿病的研究。
产品描述
PTP1B-IN-4 is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.
体外活性
In CHO cells overexpressing human IR, PTP1B-IN-4 (250 μM) stimulates the phosphorylation of insulin receptors. PTP1B-IN-4 induces phosphorylation of IRS-1 and Akt which are proteins downstream of the insulin receptor[3].
Cas No.
765317-72-4
分子式
C26H19Br2N3O7S3
分子量
741.45
别名
FRJ;PTP1B inhibitor 2;PTP1BIN2;PTP1B-IN-2;PTP1B-inhibitor-2;PTP1B IN 2;PTP1B-IN-4
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years