Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.

126088-82-2

C38H43N5O8

697.78

QWF

DMSO:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years