Squarunkin A hydrochloride 是一种有效的选择性UNC119-货物相互作用抑制剂。Squarunkin A hydrochloride选择性地抑制Src 激酶 N 末端的肉豆蔻酰化肽与 UNC119A 的结合，IC50 值为 10 nm。Squarunkin A hydrochloride 会干扰细胞中Src激酶的活化。

Squarunkin A hydrochloride is a potent and selective UNC119-cargo interaction inhibitor. Squarunkin A hydrochloride selectively inhibits the binding of a myristoylated peptide representing the N-terminus of Src kinase to UNC119A with an IC50 value of 10 nm. Squarunkin A hydrochloride interferes with the activation of Src kinase in cells [1].

Squarunkin A (2.5 μM, 0.625 μM, 0.078 μM, and 0.01 μM) treatment results in a concentration-dependent reduction of Src phosphorylation [1]. Squarunkin A does not target the lipoprotein-binding sites of other lipoprotein chaperones, such as PDE6d, AIPL1, and RhoGDI, which bind S-prenylated proteins. Squarunkin A binds to UNC119 in cell lysate and interferes with Src activation [1].

2253744-55-5

C25H33ClF3N5O4

560.01

Squarunkin A hydrochloride

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years