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Lipid 5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lipid 5图片
CAS NO:2089251-33-0
包装与价格:
包装价格(元)
50 mg电议
100 mg电议

产品介绍

产品描述

Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.

体外活性

Replacement of the linoleic tail with a primary ester-containing lipid tail (Lipid 5) provids increased expression and optimal tissue clearance. The metabolite identification studies with Lipid 5 indicated that hydrolysis of the primary ester is the first step in the metabolism of the lipid[1].

体内活性

Clearance of Lipid 5 and MC3 from multiple mouse tissues is measured after dosing 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. Liver and spleen have the highest levels of Lipid 5, however, significantly lower levels than MC3. Lipid 5 is detected in plasma, lung, and kidney, but not in heart[1].

Cas No.

2089251-33-0

分子式

C44H87NO5

分子量

710.182

别名

Lipid 5

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years