Metarrestin 是一种口服有效的选择性核仁周区室 (PNC) 抑制剂，可有效抑制转移。。它破坏核仁结构并抑制RNA 聚合酶 (Pol) I转录，部分是通过与翻译延伸因子 eEF1A2 的相互作用。

Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2.

1443414-10-5

C31H30N4O

474.6

ML246;Metarrestin

DMSO:31.25 mg/mL (65.84 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years