8-CPT-2Me-cAMP 钠盐是exchange proteins activated by cAMP (Epac)的选择性激动剂，Epac 是小 GTP 酶 Rap1 和 Rap2 的 cAMP 敏感性鸟嘌呤核苷酸交换因子 (GEF)。8-CPT-2Me-cAMP 是cAMP 类似物，可激活Epac1(EC50=2.2 μM)，但不激活 PKA(EC50>10 μM)。8-CPT-2Me-cAMP 在体外刺激Epac 介导的 Ca2+ 在胰腺 β 细胞中的释放。

8-CPT-2Me-cAMP sodium is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 ( EC 50 = 2.2 μM), but inactive PKA ( EC 50 >10 μM) [1]. 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca 2+ release in pancreatic β-cells in vitro [2].

634207-53-7

C17H16ClN5NaO6PS

507.82

8-CPT-2Me-cAMP, sodium salt

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years