Potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats in vivo, blocks urocortin-induced hypotension following systemic administration.

434938-41-7

C162H276N48O46

3632.26

K 41498;K41498

H2O:5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years