您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > GLP-1(7-36),amide acetate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
GLP-1(7-36),amide acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GLP-1(7-36),amide acetate图片
CAS NO:1119517-19-9
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议

产品名称
Human GLP-1-(7-36)-amide Acetate
GLP-1(7-36) Acetate
GLP-1(7-36), amide acetate
产品介绍

产品描述

GLP-1(7-36) Acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.

体外活性

Cells treated with phorbol 12-myristate 13-acetate for 2 h has significantly higher active GLP-1(7-36) concentrations in the media compares to the control. The glucose treatment also increases active GLP-1 secretion from cells in dose-dependent manner. Palmitic, oleic, linoleic or linolenic acid dose-dependently stimulated active GLP-1 secretion from cells. Active GLP-1 secretion is significantly greater with unsaturated fatty acids such as oleic, linoleic and linolenic acids than with palmitic acid. The treatment of NCI-H716 cells with CPE dose-dependently increases active GLP-1 concentrations in the media. A 37% increase is observed in active GLP-1 secretion from these cells at a concentration of 0.1 % CPE[1].

体内活性

Gastric administration of glucose increases active GLP-1(7-36) amide levels in the portal blood after 10 min, followed by a marked decrease at 30 min. The gastric administration of TO also increases active GLP-1 levels after 10 min, and followed by a decrease to basal levels at 60 min. Individually, glucose and TO increase the secretion of GLP-1 in a dose-dependent manner. Moreover, the co-administration of glucose and TO additively increase peak GLP-1 levels. CPE-administered mice have higher active GLP-1 levels in the portal blood at 10 and 30 min than those in the control mice. The active GLP-1 and insulin levels in the portal blood are slightly higher in CPE-administered mice than in the control mice when glucose is administered with CPE. High-fat diet-fed C57BL/6J mice develop hyperglycaemia and impair glucose tolerance[1].

Cas No.

1119517-19-9

分子式

C149H226N40O45.xC2H4O2

别名

Human GLP-1-(7-36)-amide Acetate;GLP-1(7-36) Acetate;GLP-1(7-36), amide acetate

储存和溶解度

H2O:50 mg/mL (14.73 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years