Odatroltide, as a nanoscale P-selectin inhibitor, is a nano-delivery system of 6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and KPAK to target the thrombus.

Odatroltide (1 nM) effectively down-regulates P-selectin expression. DHDMIQK(KAP) effectively inhibits platelet aggregation via down-regulating the expression of P-selectin. Odatroltide effectively inhibits platelet aggregations induced by TH, AA, ADP and PAF, which are correlated with the downregulation of P-selectin expression and with the scavenging of the free radicals[1].

Odatroltide (0.01 nmol/kg) lyses the thrombus and inhibits thrombosis with a minimal[1].

1639303-73-3

C32H51N7O8

661.801

DHDMIQK(KAP);Odatroltide;Odatroltide

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years