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NIR-Thiol dinitrobenzenesulfonate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NIR-Thiol dinitrobenzenesulfonate图片
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品介绍

产品描述

NIR-Thiol dinitrobenzenesulfonate has both absorption and emission in the NIR region. It is capable of imaging endogenously produced thiol in living cells and mice.

体外活性

NIR-Thiol dinitrobenzenesulfonate is highly selective to typical small molecular weight biological thiols (Cys, Hcy, and GSH) over other biorelevant species, such as Phe, Gly, Arg, Lys, Tyr, Leu, glucose, Ser, and Val. The sensor NIR-Thiol dinitrobenzenesulfonate is incubated with living HeLa or Bel 7702 cells, and bright fluorescence is observed. NIR-Thiol dinitrobenzenesulfonate has some prominent features, including NIR absorption and emission, rapid response, high sensitivity, excellent selectivity, good cell membrane permeability, and low cytotoxicity.

体内活性

A different amount (0, 20, 40, or 160 nmol) of NIR-Thiol dinitrobenzenesulfonate is injected into the i.p cavity of mice. Strong fluorescence is noted for the mice injected with 20 nmol of NIR-Thiol dinitrobenzenesulfonate, whereas almost no fluorescence is observed in the control mice. In addition, the mice injected with a higher amount (40 or 160 nmol) of NIR-Thiol dinitrobenzenesulfonate provides brighter fluorescence. A very large signal-to-noise contrast ratio (ca. 700-fold enhancement) is observed for the mice injected with 20 nmol of NIR-Thiol dinitrobenzenesulfonate. In addition, the signal-to-noise contrast ratio jumped to ca. 2900- or 7400-fold enhancement when the mice are injected with 40 or 160 nmol of NIR-Thiol dinitrobenzenesulfonate, respectively.

Cas No.

T19039

分子式

C39H33N5O15S2

分子量

875.83

别名

NIR-Thiol dinitrobenzenesulfonate

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years