TSHR antagonist S37a is a selective antagonist of thyrotropin receptor (TSHR), with potential for the treatment of Graves' orbitopathy.

In HEK293 cells, TSHR antagonist S37a is an inhibitor of TSHR(IC50s of 40 μM and approximately 20 μM for mTSHR and hTSHR, respectively). TSHR antagonist S37a also activation by monoclonal TSAb M22 (human), KSAb1 (murine), and the allosteric small-molecule agonist C2.

In GO patients' sera, TSHR antagonist S37a inhibits cyclic adenosine monophosphate formation by oligoclonal TSAb, which are highly enriched.

2143452-20-2

C25H20N2O3S2

460.57

TSHR antagonist S37a

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years