15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys. 15(S)-Latanoprost is a potential impurity in most commercial preparations of the latanoprost bulk drug product.

145773-22-4

C26H40O5

432.59

15(S)-Latanoprost

DMSO:PBS (1:12):80 μg/mL
DMSO:100 mg/mL
DMF:100 mg/mL
Ethanol:100 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years